When Evansville College first moved to the campus on Lincoln Avenue, chapel services were held in the Administration Hall. However, within just a few years, the ever-increasing enrollment made this arrangement impossible. In 1964 a generous gift from Mr. and Mrs. Adam J. Neu enabled the University to build Neu Chapel.

Neu Chapel is constructed of Indiana limestone and the roof is shingled with Vermont slate. The high-arching, wooden ceiling eclipses the neo-Gothic, outer design. The balcony hosts a choir loft and a fine Holtkamp organ, while the sanctuary seats 450 comfortably. Completed in December 1965, the inaugural service was held on January 6, 1966. Neu Chapel was dedicated by United Methodist Indiana Area bishop, Richard C. Raines on March 15, 1966.

Neu Chapel houses the offices of the University Chaplain and University Organist, an inter-faith, 24-hour prayer room, Grabill Lounge, and the Wesley Gallery. In a blackout, Grabill Lounge is rumored to be the darkest place on campus. A large closet at the back of the Wesley Gallery doubled as a bomb shelter during the Cold War.

The Chapel is used for worship services, special ecclesiastical events, weddings and funerals, but also hosts concerts, lectures, community forums, and campus ceremonies.